Brief Definitive Report ASSOCIATION OF SERUM HEMOLYTIC COMPLEMENT LEVELS WITH THE MAJOR HISTOCOMPATIBILITY COMPLEX IN CHICKENS* BY TRAN CONG CHANH, ALBERT A. BENEDICT, AND HANS ABPLANALP
نویسندگان
چکیده
The B blood group locus in the chicken (1) represents the avian counterpart of the major histocompatibility complex (MHC) of mammals. It is associated with allograft rejection (2), the graft-vs.-host reaction (3, 4), the mixed leukocyte reaction (5), and immune responsiveness to synthetic polypeptide antigens (6, 7). As yet, none of these functions can be assigned to any particular region within the B complex as has been done with the human (HL-A) and mouse (H-2) MHC (8). Therefore, to determine the genetic relationships of the B complexassociated functions, we were motivated to search for additional immunologic functions controlled by genes associated with the chicken MHC. Also linked to HL-A in man (9) and to the Ss locus in the S region of the H-2 complex (10, 11) are genes which influence serum complement (C) levels. In this report we present the first evidence that the total hemolytic C level in chickens is controlled by a gene(s) associated with the MHC, thus providing further evidence that the B blood group locus is the avian homologue of the mammalian MHC.
منابع مشابه
Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites
C-reactive protein (CRP) concentrations rise in response to tissue injury or infection. Circulating pentameric CRP (pCRP) localizes to damaged tissue where it leads to complement activation and further tissue damage. In-depth knowledge of the pCRP activation mechanism is essential to develop therapeutic strategies to minimize tissue injury. Here we demonstrate that pCRP by binding to cell-deriv...
متن کاملHuman cytomegalovirus-derived protein UL18 alters the phenotype and function of monocyte-derived dendritic cells.
Human cytomegalovirus (HCMV) encodes the MHC class I-like molecule UL18, which binds with high affinity to the leukocyte Ig-like receptor-1 (LIR-1), an inhibitory receptor commonly expressed on myeloid cells and subsets of NK and T cells. The exact role of UL18 is not known, in particular in relation to its proposed role in HCMV immune escape. Given the ubiquitous expression of LIR-1 on dendrit...
متن کاملLymphocyte Activation and Function 2 B 4 / CD 48 - Mediated Regulation of Benedict J . Chambers and Hans - Gustaf Ljunggren
متن کامل
Induction of protective CTL immunity against peptide transporter TAP-deficient tumors through dendritic cell vaccination.
A large proportion of human cancers show deficiencies in the MHC class I antigen-processing machinery. Such defects render tumors resistant to immune eradication by tumoricidal CTLs. We recently identified a unique population of CTL that selectively targets tumor immune-escape variants through recognition of MHC-presented peptides, termed TEIPP (T cell epitopes associated with impaired peptide ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2003